It's a dog-eat-dog world for bacteria, many of which have developed mechanisms to deliver diverse toxins into one another. The purpose of this mini-symposium is to bring together scientists working in the broad area of bacterial toxin delivery systems including colicins, contact-dependent growth inhibition (CDI) and Type 6 secretion systems (T6SS). We will hear the latest developments in understanding how toxins are delivered into target cells and inhibit cell growth. There will be time for discussion and brainstorming regarding the latest developments, unpublished data, and new ideas. This will include ideas for harnessing knowledge of these toxin delivery systems to combat drug-resistant bacterial pathogens. Examples include possible use of peptides, phage, R-type pyocins and other vehicles to target bacterial pathogens.